Mirvaso® 3mg/g Gel (Brimonidine)

What is Mirvaso® Gel used for​​​?

Mirvaso® Gel is the first FDA-approved treatment developed and indicated for persistent (nontransient) facial redness of rosacea. It contains the active ingredient Brimonidine, which is used to treat a skin condition called rosacea. Rosacea is a skin condition that affects parts of your face. Symptoms of rosacea include flushing, redness, and small lumpy red spots. Although it can look similar to 'teenage' acne, it is an unrelated condition.

Mirvaso® Gel is used to reduce redness of the skin in people with rosacea. It works by narrowing the blood vessels in the skin which in turn reduces blood flow in the skin and reduces the appearance of redness.

What to expect from treatment with Mirvaso® Gel?

In clinical studies, subjects who used Mirvaso® Gel saw their redness diminished for up to 12 hours. And for many, redness began to fade fast— often in as little as 30 minutes.

On day 29 of the trials, 2-grade improvement in redness was observed with Mirvaso® Gel vs vehicle gel at hour 3 (28% vs 10%), at hour 6 (28% vs 9%), at hour 9 (22% vs 10%), and at hour 12 (22% vs 9%).

In a 1-year clinical trial, subjects who used Mirvaso® Gel daily for at least 12 months had consistent results—from day 1 through day 365.

The effect of Mirvaso® Gel is powerful - skin that has been red for days, months, or even years may suddenly look "normal" again. However, it is important to note that Mirvaso® Gel is not a cure for Rosacea. Your redness will return after the effect of the medication wears off. Avoid your triggers, even while you are using Mirvaso® Gel. As with any treatment, results can vary.

Dosage and How to Use​

Mirvaso® Gel (Brimonidine 0.33%) should always be used as instructed by your doctor. Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer’s leaflet will give you more information about how to use the medicine correctly. Generally, the steps are as follows:

• Mirvaso® Gel should be applied once a day.
• Apply Mirvaso® Gel thinly and evenly over the whole face including forehead, nose, chin and both cheeks. Avoid contact with your eyes and lips. Do not apply Mirvaso® Gel to open wounds or irritated skin.
• The maximum recommended amount of gel to be used is five pea-sized amounts, but it is usual to start by using smaller amounts.
• Wash your hands immediately after application.
• Do not apply more than the recommended amount or more often than once daily.
• You can apply makeup after Mirvaso® Gel dries.
• Mirvaso® Gel can be used with other creams, ointments or gels for the treatment of rosacea. If you are using more than one skin product, apply Mirvaso® Gel first and allow it to dry before applying anything else.

What are the possible side effects of Mirvaso® Gel?​

In clinical trials, the most common side effects that occurred in at least 1% of subjects included redness, flushing, skin burning sensation, and contact dermatitis. It may be recommended to use smaller amounts of gel until you know how your skin reacts, then gradually increase the amount used, up to the maximum (5 pea sized pumps).

Some subjects reported worsening of redness while using Mirvaso® Gel. Stop the medication and inform your doctor if this occurs. In studies, this side effect was temporary and went away on its own once the medication was stopped.

What precautions should I take?

Inform your healthcare professional if: 

• If you are pregnant, trying for a baby, or breastfeeding.
• If you have severe or unstable cardiovascular disease.
• If you ever experience dizziness when standing (due to low blood pressure).
• If you have problems with your blood circulation, such as in Raynaud's syndrome or Buerger's disease.
• If you have an immune system disorder called scleroderma.
• If you have Sjögren's syndrome.
• If you have ever had an allergic reaction to a cream or gel.
• If you have depression or are taking certain antidepressant medicines.
• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

A National Rosacea Society survey identified sun as the #1 rosacea trigger. Minimizing exposure to sun by wearing protective clothing or applying a sunscreen with an SPF of 30 or higher may help.

Handling and storage

• Store in a cool, dry place, away from direct sunlight.
• Keep out of sight and reach of children.

The above information answers some common questions about this medicine. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

References

https://www.mirvaso.com/