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Naltrexone/Bupropion 120s is an FDA-approved dual-action weight loss medication in the form of an oral formulation, containing 8mg of Naltrexone and 90mg of Bupropion. It is a combination medication meant to target areas of the brain tied to cravings and appetite.
Naltrexone/Bupropion 120s was studied for efficacy and safety in 3 clinical trials with over 2322 patients. Across the 3 different clinical studies, patients struggling with obesity who took this medication, along with diet and exercise, lost 2-4 times more weight over 1 year than with diet and exercise alone.
Study 1: COR-1
Study 2: COR-BMOD
Study 3: COR-Diabetes
Naltrexone/Bupropion 120s is a long-term approach to help you achieve sustainable weight loss results. Your results may vary depending on your weight, body mass index (BMI), diet, activity level, and other factors.
Naltrexone/Bupropion is designed to be introduced to the body gradually. The dosing starts at a lower level and increases over time, allowing the body to adjust to the medication.
Starting: Week 1: one tablet in the morning
Week 2: one tablet in the morning, one tablet in the evening
Week 3: two tablets in the morning, one tablet in the evening
Week 4 onwards: two tablets in the morning, two tablets in the evening
If you miss a dose of Naltrexone/Bupropion, skip that dose and wait until your next regular time to take it. Do not take more than 1 dose of Naltrexone/Bupropion at a time. Never take a double dose to make up for a dose you have missed.
Naltrexone/Bupropion is a medication that, while effective for weight loss, can come with a range of side effects including nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
To help manage these potential side effects, Naltrexone/Bupropion is designed to be introduced to the body gradually. The dosing starts at a lower level and increases over time, allowing the body to adjust to the medication and thereby reduce the severity of any side effects.
Inform your doctor if the side effects above become severe and bother you.
Inform your healthcare professional if:
Please inform your healthcare professional about all the medicines and supplements you take, especially the following medicines:
Please inform your healthcare professionals that you are taking Naltrexone/Bupropion if you are seeing them for other medical conditions.
Drinking alcohol with Naltrexone/Bupropion may increase your risk of seizures. If you drink alcohol regularly, talk to your doctor before changing the amount you drink. Bupropion can also cause seizures in a regular drinker who suddenly stops drinking.
The above information answers some common questions about this medicine. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.
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