Epiduo® Gel 0.1%/2.5% Pump

What is this medication used for​​​?

Epiduo® Gel 0.1%/2.5% Pump contains Adapalene and Benzoyl Peroxide which work together but in different ways for the treatment of acne.

Adapalene is a type of retinoid. It works by exfoliating the skin (removing dead skin cells) to prevent blocked pores and soothe inflammation. Benzoyl Peroxide is an antimicrobial agent that works to soften and peel the skin’s outer layer as well as tackle the microbes that can trigger acne.

The combination of Adapalene and Benzoyl Peroxide

The combination of the two active ingredients offers a comprehensive approach to acne treatment, making it an efficient choice for many individuals with acne-prone skin.

Adapalene and Benzoyl Peroxide together complement each other’s actions. On one hand, adapalene promotes skin cell turnover and reduces inflammation, on the other, Benzoyl Peroxide fights acne-causing bacteria and mitigates excess sebum production. 

Studies have shown that more than 70% of patients observed a huge reduction of inflammatory and non-inflammatory acne breakouts over a 12-week period by applying it once at night.

What is the difference between Epiduo and Epiduo Forte Gel?

The main difference between these two medications is the strength of Adapalene:

Epiduo contains: Adapalene 0.1%, Benzoyl Peroxide 2.5% - suited for ages 9 and above.

Epiduo Forte is stronger and contains: Adapalene 0.3%, Benzoyl Peroxide 2.5% - suited for ages 12 and above.

Dosage and How to Use​

• Wash the skin with cleanser, then rinse and pat dry.
• Wash your hands before and after applying the medication.
• Apply a thin layer of medication to cover the affected areas once a day at bedtime or according to your doctor’s instructions.
• Avoid applying the medication on broken skin or too near to your eyes, mouth and nose as it may cause irritation. 
• Flush the area thoroughly with water if the medication accidentally gets into your eyes, mouth, and nose.

What to do if I missed a dose?

If you forget to apply a dose of this medication, apply it as soon as you remember. Skip the dose if it is time for the next dose. Apply your next dose at the usual time. Do not apply two doses to make up for the missed dose.

What are the possible side effects of the medications?​

Skin redness, dryness, peeling, mild burning, swelling, or worsening of acne may occur during the first 4 weeks of using this product. These effects usually decrease with continued use.

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following: 

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

If you experience any of the following side effects, please consult your doctor immediately:

• Burning
• Blistering
• Crusting
• Itch
• Swelling

What precautions should I take?

Inform your healthcare professional if: 

• You are allergic to this medication or any of the other ingredients of this medication
• You are pregnant, planning to become pregnant, or breastfeeding

Avoid washing your face too often as this may increase the drying-out effect of your medication. Wash your face two to three times a day only.

Unless otherwise directed by your doctor, avoid using other “drying” preparations on the same treated areas to prevent severe irritations. These include harsh soaps and cleansers, alcoholic preparations and medicated cosmetics or soaps. 

Avoid using Epiduo on areas where you have cuts, scrapes, sunburn or eczema.

Avoid staying directly under sunlight for long durations. Use a broad-spectrum sunscreen product with Sun Protection Factor (SPF) of at least 30 and wear protective clothing when you are exposed to direct sunlight.

Avoid applying heavy make-up and using oily cosmetics. It is recommended to choose make-up products with non-oily formulas.

Avoid getting Epiduo on your hair or coloured fabrics as it may bleach them and wash your hands thoroughly after you have used the medicine.

Handling and storage

• Store in a cool dry place, away from direct sunlight.
• Keep out of sight and reach of children.

The above information answers some common questions about this medicine. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

References

https://www.webmd.com/drugs/2/drug-151655/epiduo-topical/details

https://www.medicines.org.uk/emc/files/pil.451.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840853/